| Sign, symptom, or condition | Sign of, and Treatment | Reference |
| Sunken eyes | Dehydration; Patient may need referral to Doctor or urgent rehydration, depending on severity. Patient may benefit from blood tests | Johnson and Smith, 2012: 94. |
| High NEWS2 Score | Sepsis; patient may need antibiotics and emergency treatment | Royal College of Physicians, 2017 |
| Covid-19 | The diarrhoea could be a sign of deterioration, but the evidence for this is weak | Amico et al, 2020 |
| Female and increased age | Increased risk of dehydration | Rowat et al, cited in Sweetser, 2012 |
| Heart or kidney failure; take steroids | Increased risk of overhydration; patient may require emergency treatment | Sweetser, 2012; WHO, 2021. |
| Dizziness | Dehydration; patient may require urgent rehydration | Sweetser, 2012; WHO, 2021 |
| Confusion; seizures | Dehydration or overhydration; electrolyte imbalances; patient may require emergency treatment and urgent rehydration | Sweetser, 2012; WHO, 2021 |
| Type 2 Diabetes; metformin | Metformin can cause the symptoms; diabetes is a risk factor due to potential difficulties managing the condition | Johnson and Smith, 2012: 96 |
| Immunosuppressed | Risk of deterioration | Johnson and Smith, 2012: 96 |
| Bowel disease such as ulcerative colitis or diverticulitis | May indicate more severe illness | Johnson and Smith, 2012: 96 |
| Blood in stools | May be an indication of abdominal bleeding | Johnson and Smith, 2012: 96 |
